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ea0029p31 | Adrenal cortex | ICEECE2012

Analysis of the glucocorticoid receptors polymorphism in patients with adrenal incidentaloma and patients with Cushing’s syndrome.

Reimondo G. , Giachino D. , Micossi I. , Berchialla P. , Varacalli S. , Allasino B. , Pia A. , Laino F. , Peraga G. , Cosio P. , Sciolla C. , De Marchi M. , Terzolo M.

The effects of glucocorticoids are mediated by the glucocorticoid receptors (GR) and some single nucleotide polymorphisms (SNPs) have been associated to enhanced sensitivity (N363S, BclI) or reduced sensitivity (ER22/23EK) to glucocorticoids.Aim of the present study was: 1) to assess the frequency of N363S, BclI and ER22/23EK in 46 patients with Cushings syndrome (CS) and 73 patients with adrenal incidentaloma (AI) compared to 186 healthy subjects;...

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Analysis of the glucocorticoid receptors polymorphism in patients with adrenal incidentaloma and patients with Cushing’s syndrome.

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